Opioid Addiction
Drug Effects
Heroin and other opioids enter the brain rapidly and bind to opioid receptors on cells located in many areas, especially those involved in feelings of pain and pleasure and in controlling heart rate, sleeping, and breathing.
Withdrawal Effects
Those who are addicted to heroin and stop using the drug abruptly may have severe withdrawal. Withdrawal symptoms—which can begin as early as a few hours after the drug was last taken—include:
- Restlessness
- Severe muscle and bone pain
- Sleep problems
- Diarrhea and vomiting
- Cold flashes with goose bumps (“cold turkey”)
- Uncontrollable leg movements (“kicking the habit”)
- Severe heroin cravings
Researchers are studying the long-term effects of opioid addiction on the brain. Studies have shown some loss of the brain’s white matter associated with heroin use, which may affect decision-making, behavior control, and responses to stressful situations.6–8